Tuesday, April 30, 2013

Benchmark's Bill Gurley Says New York Has The Engineers And Entrepreneurs, Now It Needs Big Iconic Companies

gurleyWhat are the challenges that the New York tech scene needs to address? This topic kicked off the conversation this morning between TechCrunch founder Michael Arrington and venture capitalist Bill Gurley?at TechCrunch Disrupt NY 2013. Gurley’s?VC firm, Benchmark, has invested in some of the most disruptive technology companies over the past 10 years, including Dropbox, Zillow, Uber, Twitter and Snapchat. He says that New York needs more iconic companies, and worries about the Wall Street influence on the New York tech community. Gurley noted that what really put Seattle on the map were companies he described as “four pillars” of the Seattle market ?- companies that people identify as being associated with Seattle: specifically, Microsoft, Starbucks, Amazon, and Costco. He says that all of these were originally venture-backed and have remained ?throughout the years. New York has the?entrepreneurs?and the engineers, says Gurley. Now the city needs its own “iconic” companies to put it on the map, as well. There’s no?precedent?for that here just yet, he adds. But when pressed on whether or not New York didn’t have “big” companies, Gurley admitted that VC’s think of DoubleClick as one of the big exits here, and more recently, he says, there was the exit of Connecticut-based job site Indeed. “[Indeed] had a great business model, a huge consumer brand…and they sold it,” scoffed Gurley. “I think in general, in the venture business we have this problem – this kind of anti-IPO attitude – that I think prohibits companies from hitting the long ball, but it seems like maybe that’s even more acute here.” Venture capitalists are dependent on huge home runs – big wins. He said the system dynamic in New York prevent companies from reaching that point. The mentality in New York is one that’s still associated with that found on Wall Street, Gurley said. That is, Wall Street is not loyal to companies, but is more focused on the dollars and bottom line. This can prevent companies from growing large, turning into the kind of iconic firms that could one day become pillars of the New York tech community, the way that Microsoft et al. have become?synonymous with Seattle. Earlier this morning,?Andreessen Horowitz’s Chris Dixon spoke?of other, but somewhat similar,?concerns, when?comparing the general climate for startups in New York to those in San Francisco.??There are plenty of great investors here and attracts lot of entrepreneurs,” he had. But he saw

Source: http://feedproxy.google.com/~r/Techcrunch/~3/yHxRwTh2HS0/

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How does pregnancy reduce breast cancer risk?

Apr. 28, 2013 ? Being pregnant while young is known to protect a women against breast cancer. But why? Research in BioMed Central's open access journal Breast Cancer Research finds that Wnt/Notch signalling ratio is decreased in the breast tissue of mice which have given birth, compared to virgin mice of the same age.

Early pregnancy is protective against breast cancer in humans and in rodents. In humans having a child before the age of 20 decreases risk of breast cancer by half. Using microarray analysis researchers from Basel discovered that genes involved in the immune system and differentiation were up-regulated after pregnancy while the activity of genes coding for growth factors was reduced.

The activity of one particular gene Wnt4 was also down-regulated after pregnancy. The protein from this gene (Wnt4) is a feminising protein -- absence of this protein propels a fetus towards developing as a boy. Wnt and Notch are opposing components of a system which controls cellular fate within an organism and when the team looked at Notch they found that genes regulated by notch were up-regulated, Notch-stimulating proteins up-regulated and Notch-inhibiting proteins down-regulated.

Wnt/Notch signalling ratio was permanently altered in the basal stem/progenitor cells of mammary tissue of mice by pregnancy. Mohamed Bentires-Alj from the Friedrich Miescher Institute for Biomedical Research, who led this study explained, "The down-regulation of Wnt is the opposite of that seen in many cancers, and this tightened control of Wnt/Notch after pregnancy may be preventing the runaway growth present in cancer."

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The above story is reprinted from materials provided by BioMed Central.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Fabienne Meier-Abt, Emanuela Milani, Tim Roloff, Heike Brinkhaus, Stephan Duss, Dominique S Meyer, Ina Klebba, Piotr J Balwierz, Erik van Nimwegen and Mohamed Bentires-Alj. Parity induces differentiation and reduces Wnt/Notch signaling ratio and proliferation potential of basal stem/progenitor cells isolated from mouse mammary epithelium. Breast Cancer Research, 2013 (in press) [link]

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/M01wkIKwjeM/130428230427.htm

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Today Marks Virgin Galactic's First Rocket-Powered Test Flight

Earlier this month, Virgin Chairman Richard Branson announced at the launch of Virgin America's new route through Newark that his other flying endeavor would be hitting a huge milestone this month: Its first rocket-powered test flight.

Read more...

    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/XZ-zr-iJizg/today-might-be-virgin-galactics-first-rocket-powered-t-484341889

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Saturday, April 27, 2013

Female US sailor beats the cr*p out of Dubai bus driver who tries to rape her (Americablog)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/301824532?client_source=feed&format=rss

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Beyonce Proves She's Hotter Than Ever On 'Standing On The Sun' Preview

The same day Bey teased the new track in an H&M ad, she also performed 'Grown Woman' for the first time in Paris.
By Jocelyn Vena

Source: http://www.mtv.com/news/articles/1706309/beyonce-standing-on-the-sun-hm-preview.jhtml

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Friday, April 26, 2013

HTC One in black appears on Sprint site, looks ready to order

Black HTC One

Long-awaited Black HTC One makes an appearance, complete with a button to buy today

If you've been waiting for the HTC One in black, it looks like Sprint just put it up for sale about an hour ago. Of course it's the same One as the silver version, but it's black. A few people are concerned that these aren't shipping right away, but we see nothing to suggest that on Sprint's website -- for all intents and purposes it looks like they are ready to roll out the door.

Now who is going to be the guinea pig and order the first one and see when it ships? Hash it all out in the forums.

Source: Sprint; via: Android Central forums

    


Source: http://feedproxy.google.com/~r/androidcentral/~3/zvie94h6v1c/story01.htm

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Monday, April 8, 2013

April 7, 2013 - UCR Palm Desert Low Residency MFA

The State of the Short Story: A Quick Chat with Josh Rolnick
Written By: Cynthia Romanowski ? Originally Published JAN? 18?12

I have mixed feeling about going to readings. Every month it seems like there are at least 2-3 readings around Los Angeles that I hear about. Though I dutifully mark my calendar and most times fully intend to attend them, more often than not when the day finally rolls around I?m either tired (I live in OC so it?s kind of a trek) or I go into social anxiety mode and get nervous just thinking about being around people and having to be friendly and attempt to ?mingle,? so usually I choose to stay in the dark cave that is my apartment.?Dani Shapiro?actually has an excellent?blog post?that gets into this?

But at the same time, if a reading is good?if the writing captures and whisks me away for a while (mitigating said social awkwardness)? I feel like there is nothing is more invigorating. As a writer, a great reading is like a B-12 vitamin for motivation, especially if I?m in a slump. And it often reminds me why I write, why I spend all this time struggling to create these stories, it?s about that connection. That shared emotional experience and understanding that comes from a well-crafted piece of prose.

Back in September, I attended a reading that had just that effect, it was at?Skylight Books?in Los Feliz and?Edan Lepucki?was reading with?Josh Rolnick?who was reading from his new short story collection??Pulp and Paper.??After the reading they interviewed each other briefly (they both went to Iowa for their MFA?s) and what stood out to me was what Josh had to say about his experience as a short story writer in today?s market.

So just in case you missed the reading for geographical reasons or if you decided to stay in the cave like I so often do, I went ahead and sent Josh some questions to try and re-invent the evening a bit (for full effect you?ll have to pick up his book and Edan?s?novella).

Here?s what he had to say:

1)??? Your new book ?Pulp and Paper? is a debut collection of short stories that all take place in Brooklyn, first off how long have you been working on this collection? Are any of these stories ones that you worked on at Iowa?

Well, a slight correction. I currently live in Brooklyn. The stories are in fact divided equally between New Jersey and New York state. But they range all across the two states. They are set in the suburbs and in the city; at the Shore and in the mountains. My hope is that the settings give a sense of the rich geographic diversity of the neighboring states.

There is one story set in Brooklyn: ?The Carousel.? This story is about an aging carousel operator who sees the modern world kind of passing him by. But it?s the only one set in New York City.

I started writing the stories in this collection 13 years ago. That?s when I enrolled in the part-time fiction writing program at Johns Hopkins and wrote the first few lines of ?Mainlanders.? It might seem like a simple, relatively straightforward coming-of-age story, but ?Mainlanders? actually took me 13 years to complete ? I finished it in early 2011, as I was preparing my manuscript for publication.

I would say that I have been working more intensely on the book for the past 6 or 7 years ? since I enrolled in the Iowa Writers? Workshop. Most of the stories took at least 2 years to write; usually, much longer. My writing process has never been a quick one; my stories, to paraphrase John Steinbeck, tend to crawl onto the page. It?s a process of writing, revising, showing the work to readers, and then repeating the process, and it usually takes me several months before I even know what the story is really about.

I started half of the stories in the collection (?Innkeeping,? ?Mainlanders,? ?Big Lake,? ?Carousel?) at Johns Hopkins, before I got to Iowa. Four (?Funnyboy,? ?Big River,? ?Pulp and Paper,? ?The Herald?) were started at Iowa. I actually find that it?s easier sometimes to write about a place once you leave it ? and it works its way into your imagination ? so who knows, maybe the next thing I write will be set in Iowa City.

2) ? That was going to be my next question! ??Since you?ve moved around the country a lot and lived in many different places, do you think it?s easier to write about a place while you?re living there or once you?ve gotten away from it for a while?

Ah ? see above. Robert Olen Butler, a writer I admire greatly, talked about the importance of ?forgetting? for fiction writers. He tells a great story. After he got out of the Vietnam War, he wrote a book set in Vietnam that was, as he tells it, not very good. Years later, after he ?forgot? the details of life in Vietnam to some extent ? and his imagination and subconscious mind took over ? he wrote another book about Vietnam. That book is the short story collection ?Good Scent From a Strange Mountain? ? which won the Pulitzer Prize.

I do think there?s something to this. When we live in a place, it sometimes fails to inspire us or become grist for our imagination. It?s just ?home? ? the place we pay bills and take out the trash and ride to work in traffic. Once we leave, though, it?s as if the dimensions of the place expand. It?s not constrained anymore by familiarity. We are able to ?see? things we never saw when we lived there ? the falling down barn on the side of the field that we passed umpteen times on the way to work but never really looked at; that mysterious guy with the scraggily hair who was always circling classifieds in the coffee shop; the sound of the train horn after midnight on the tracks you?d almost forgotten were in the woods behind your home. It?s as if imagination is freer to take over ? and you can therefore better appreciate the limitlessness of a place ? once you?ve moved on.

There are I?m sure a million exceptions to this rule. Many, many people?do?write about where they live. In my case, I?ve always been more drawn to places I?ve?left.

3)??? Can you talk a little bit about your experience as a short story writer in today?s publishing market, which seems to be primarily interested in novels/novelists? I know you have a great anecdote about a novel you once conjured on the spot to an interested agent?

That?s true. When I was in Iowa, agents used to come to meet with students. I really appreciated those visits ? it was a great chance to learn more about how the industry worked. The thing was, most of the agents were not ultimately interested in representing me, because I was working on a book of stories ? not a novel. Inevitably, in our conversations, we?d get to a point where they?d say: ?I really like your stories ? are you working on a novel?? Which can get frustrating over time.

In one of my meetings, when an agent got around to asking me if I was working on a novel, I decided ? what have I got to lose? I told her that in fact, yes, I was working on a novel. She wanted details. So I started making them up on the spot. I told her I was working on a book set on the Jersey Shore in the time before the Coast Guard. I knew from research I?d done for a short story that they used to have these things called ?Saving Stations? ? shacks along the beach manned by locals who would keep watch during a storm; if they spotted a foundering ship, they?d row out to try to rescue people. I told her my novel was about a shipwreck in a terrible storm, a love story about a young saving station tough and the girl he saves in the surf. The problem was ? I hadn?t written a single word.

She looked at me across a big wooden table. I was all-but-certain I?d ruined my career as a writer before it?d even started. That?s when she smiled and said: ?I love it!? She was ready to represent me on the spot.

This story aside, I really have had a lot of good fortune in my career as a story writer. Six of the eight short stories that appear in ?Pulp and Paper? were first published in literary journals ? from?The Harvard Review?to?Arts & Letters?? and two of those won national fiction awards. I find writing and submitting short stories for publication a great way for young writers to get their work in front of editors and, if they?re lucky, even a few readers.

I should say ? now that my collection of short stories has been published, I?ve seen a very different side of the industry. I was very fortunate that my collection won the John Simmons Short Fiction Award ? which comes with publication by the University of Iowa Press. Since my book came out in October, I have travelled the country on a book tour, reading mostly at independent bookstores, and have found people incredibly receptive to the short story form. All told, more than 600 people came out to my readings ? nearly 20 events. It may be true that short story collections don?t sell as well as novels ? but it?s also true that there are still a lot of people interested in reading short stories and exposing themselves to the form.

4)??? What is it about short fiction that appeals to you as a writer as opposed to a longer narrative structure?

In the introduction to the 1997 edition of The Best American Short Stories, Annie Proulx writes that stories have ?a trimmed, useful tautness implying a function for the reader beyond entertainment.? She continues: ?We accept the idea that there is some nugget of embedded truth in a short story.? This is exactly why I love short stories. It?s emotion achieved through compression. It?s almost as if the author is saying to the reader: See these five pages? This is all there is. This is all you need to know about this particular person?s life, in order to ?get? what I?m trying to convey. Nail down the furniture. A cyclone?s coming through.

One of my all-time-favorite short stories is ?The Wig? by Brady Udall. It?s five paragraphs long ? less than a page. It?s about an 8-year-old boy who finds a wig in a dumpster and puts it on. His dad tells him to take it off, but the boy ignores him, munching his breakfast cereal. The dad suddenly remembers a moment ?real or imagined? from ?before the accident?: his wife, her hair slightly darker than the wig, sitting in that same chair where his son sits, reading the paper to see how the Blackhawks did. He walks over, picks up his son, holds him against his chest, puts his nose to the wig. His son hugs him, ?and for maybe a few seconds we were together again, the three of us.? It?s a devastating moment, suffused with loss and yearning. That dad might be 40-something-years old ? but we don?t need 40 years of his life; we don?t need to know the wrong or right turns he took in his life, who his ancestors were or what ship they came over in; the only thing we need to know to understand him in that moment can be conveyed in one short scene, just a few hundred words. It?s like a swift, hard punch to the gut. Any longer, and it would lose some of its beauty and power.

This is what I love about short stories. This payoff. The way the best stories can show us, to paraphrase Anne Lamott, the ways in which we take care of one another. And also let us feel it.

5)??? Can you talk about how you approach fiction vs. your work as a journalist, do these different areas inform one another in any way?

Sure ? they are totally different. When I write nonfiction, say a magazine piece, I?ve got my materials around me ? interview questions, quotes, facts, background ? and a vague sense of how it might all come together in a way that makes sense for a reader.

When I sit down to write fiction, I have absolutely no idea where I?m going or what I?m going to be writing about. I may start with an image, or a scent, or a line of dialogue. I have no outline. I have not done any research. My aim is to tap into my imagination ? the dream-space, as Robert Olen Butler calls it ? to learn what it is that I?m supposed to be saying. I?m trying to find characters that seem real to me, and learn who they are, what they want, and why. The minute I start to try to ?steer? my characters with my conscious mind, the stories go off the rails. If my characters can surprise me, that tells me I?m on to something.

A big part of my education as a writer was simply learning that many writers approach their work this way. Michael Ondaatje talks about how when he wrote the ?English Patient,? he didn?t have ?any sure sense of what?s happening or even what?s going to happen.? Similarly, E.L. Doctorow says that writing a novel is like driving across country at night ? you can only see as far as the front of your headlights, but you can make the whole trip that way. I take the same approach ? writing fiction is for me an act of discovery in a way that journalism never was.

6)??? What are you currently working on?

Ah ? that?s the 60 million dollar question these days. My book came out in October, and I have been on a book tour ever since. After a decade or so writing it, I felt I needed to work full-time on getting ?Pulp and Paper? out there ? into the hands of readers, since that is in the end the whole point. Now that my tour is winding down, I will be going to work on a novel.

It?s too early to say what it?s going to be about yet. I?m just getting into the car and flipping the headlights on. Come back to me in six months or so, and I?ll let you know where I?ve been.

Source: http://palmdesertmfa.ucr.edu/blog/?p=442

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Thursday, April 4, 2013

Facebook Home Brings a Friend-Focused Home and Lock Screen to Android

Facebook Home Brings a Friend-Focused Home and Lock Screen to AndroidFacebook is not making its own phone, or a version of Android, because Facebook thinks Android works just fine. Their Facebook Home suite of apps, announced today, replaces the lock and home screens that normally hold your Android apps with updates, pictures, and messaging, all delivered through Facebook.

Put simply, Facebook thinks that you'd like to see photos and quips and links from friends, in simple full-screen display, on your phone, rather than always seeing rows of apps you might launch. That's what Facebook Home does, updating your phone with Facebook material you can double-tap to Like or comment on something. The notifications?which only come from friends, not apps and brands?will also stack up and be available to view or dismiss. Facebook Home also combines text messaging with Facebook messaging into an app called Chat Heads.

So what happens to your non-Facebook stuff? You can get to it by pressing on your own profile image in a button, roughly where the Android home button is now. You then see options to check your messages, look at your apps (divided into a "favorites" section and the full list), or head into the full Facebook app.

Facebook Home will be available starting April 12th in the Google Play Store. It's only going to support a few devices out of the gate (the HTC One X, One X+, the Samsung Galaxy S III, Note II, and soon the HTC One and Galaxy S4). Facebook says they're planning to bring it to more devices and many manufacturers have signed on to build phones with Facebook Home pre-loaded, starting with the upcoming HTC First. The pre-loaded phones will have a bit more integration, like system notifications inside Facebook Home.

For more details on how the software looks and works, check out the full walkthrough over at our sibling site, Gizmodo, and at Facebook's official announcement below.

Introducing Home | Facebook Newsroom

Original photo by Gizmodo.

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/41hzE3Ix3B0/facebook-home-is-a-friend+focused-home-and-lock-screen-replacement-%5Bupdating%5D

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Jesus Franco Dies; Horror Film Legend Was 82

Source: http://www.thehollywoodgossip.com/2013/04/jesus-franco-dies-horror-film-legend-was-82/

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Wednesday, April 3, 2013

Track who's supporting same-sex marriage now

MADRID, April 3 (Reuters) - Real Madrid 3 Galatasaray 0 - Champions League quarter-final, first leg result At the Bernabeu Scorers: Cristiano Ronaldo 9, Karim Benzema 29, Gonzalo Higuain 73 Halftime: 2-0; Teams: Real Madrid: 41-Diego Lopez; 15-Michael Essien, 2-Raphael Varane, 4-Sergio Ramos, 5-Fabio Coentrao; 6-Sami Khedira, 14-Xabi Alonso; 22-Angel Di Maria (3-Pepe 86), 10-Mesut Ozil (19-Luka Modric 80), 7-Cristiano Ronaldo; 9-Karim Benzema (20-Gonzalo Higuain 65) Galatasaray: 25-Fernando Muslera; 27-Emmanuel Eboue, 26-Semih Kaya, 13-Dany Nounkeu, 11-Albert Riera (53-Nordin Amrabat 83); ...

Source: http://news.yahoo.com/blogs/ticket/same-sex-marriage-senate-endorsement-tracker-154748412--politics.html

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